Exposure to Phenobarbital in a Foal after Nursing a Mare Treated with Phenobarbital
نویسندگان
چکیده
منابع مشابه
Comparison of Alcohol Withdrawal Outcomes in Patients Treated with Benzodiazepines Alone versus Adjunctive Phenobarbital: a Retrospective Cohort Study
Background: For treatment of severe alcohol withdrawal syndrome, high dose benzodiazepines (BZDs) may cause delirium and over-sedation. Phenobarbital (PBT) is a long-acting barbiturate effective for the treatment of alcohol withdrawal. Given the potential benefits of PBT, we sought to investigate the effectiveness of PBT as adjunctive treatment for alcohol withdrawal. Methods: This was a retros...
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Recent evidence has suggested that the induction of DNA synthesis by nongenotoxic chemical carcinogens plays an important role in the formation of cancer. The present study examined the effect of a nongenotoxic carcinogen, phenobarbital, (PB) on the induction of DNA synthesis in preneoplastic foci and adenomas in B6C3F1 mice. Male mice were treated with diethylnitrosamine at 30 days of age. Aft...
متن کاملChanges in blood coagulation-related parameters in phenobarbital-treated rabbits.
The effects of repeated administration of phenobarbital (PB) on blood coagulation time were examined using male Japanese white SPF rabbits, which are widely used for toxicological studies. PB was administered to the rabbits by oral gavage for 2 weeks, at dose levels of 0, 12.5, 25 and 50 mg/kg/day. Blood was collected on Days 8 and 14 after each day's dosing to perform blood coagulation examina...
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Previous studies have demonstrated that phenobarbital (PB) significantly impairs the biliary excretion of acetaminophen glucuronide (AG) in rats. Studies also suggested that Mrp2 mediates AG biliary excretion, and Mrp3 is involved in AG basolateral export. It was hypothesized that inhibition of Mrp2-mediated AG transport by PB or PB metabolites, and PB induction of Mrp3, may contribute to the i...
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Editorials 871 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries. 1 Approximately 85% of these people do not receive appropriate treatment 2 because of economic, cultural, social and legislative barriers, compounded by little interest on the part of pharmaceutical companies because drug distribution is not lucrative. Left untreated, peo...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2008
ISSN: 0891-6640,1939-1676
DOI: 10.1111/j.1939-1676.2007.0036.x